TF Regulon Engineering:
Reducing N₂O Emissions by Increasing NUE
in Bioenergy Crops

ARPA-E TEOSYNTE Project DE-AR0002025

The TF Regulon Engineering project is an interdisciplinary effort funded through the ARPA-E TEOSYNTE Program, focused on transforming how plants utilize nitrogen.

Nitrogen fertilizers are essential for modern agriculture but are a major source of Nitrous oxide emissions, a potent greenhouse gas and driver of climate change.

Our approach moves beyond traditional breeding and single-gene engineering. We use machine learning to target transcription factor regulons—coordinated gene networks that control nitrogen uptake, assimilation, and metabolism.